Endocrine Abstracts

Hyperthyroid patients show an impaired response or even resistance to digoxin treatment.Objectives: 1. Are there any differences in the pharmacokinetics of a single oral dose of digoxin between hyperthyroid and euthyroid patients? 2. Does simultaneous administration of digoxin and methimazole or digoxin and acebutolol affect the pharmacokinetics of a single oral dose of dogoxin? 3. Does methimazole-induced euthyroidism change the pharmacokinetics of a si...

The factors influencing the final outcomes of 131I therapy are indefinitely known, besides its practical use since more than 60 years. One of the considered factors affecting the results of 131I therapy is iodine metabolism.Aim: The aim of the study was the evaluation of the iodine uptake and the effective half-life of 131I influence on the result of radioactive iodine therapy in patients treated due to Graves’ hyper...

Aim: We compared effectiveness of partial withdrawal of levothyroxine (L-T4) to the use of recombinant human TSH (rhTSH) in preparation for Tg testing. We also evaluated clinical aspects and quality-of-life (QOL) during both regimens.Materials and methods: Ten consecutive patients, previously treated with total thyroidectomy and radioiodine ablation for DTC, underwent rhTSH protocol and, after 15 days, reduced their L-T4 dose by 50% for 5 weeks. At the f...

In 2002, we introduced metformin as an alternative treatment option of the anti-androgenic contraceptive pill in polycystic ovary syndrome (PCOS). The analysis of our observations is presented here.170 women (age 14–45 y) were diagnosed with PCOS according to the Rotterdam criteria. 88% had acne, 68% hirsutism, 46% irregular menstrual cycles, 39% BMI over 25 kg/m2, 13.5% had apple-type obesity and 4.7% acanthosis nigricans. 104/170 patien...

Introduction: Midnight salivary cortisol measurement (MSC) has been recently introduced as a diagnostic test for hypercortisolism. The aim of our study was to compare the diagnostic value of two methods of screening for Cushnig’s syndrome (CS): MSC and 24-h urinary free cortisol (UFC), wildely accepted as a ‘gold standard’ for this diagnosis.Patients and methods: Three groups were studied: 30 patients with CS (mean age±S.D.</sm...

Introduction: Lipid profile characterization in women with gestational diabetes mellitus (GDM) and its impact on post-partum dysglycemia remains to elucidate. The aim of this study was to evaluate lipid profile in women with GDM during pregnancy and 8 weeks after and to study its correlation with glycemic control.Methods: This study was carried out in a central hospital in Portugal. All women with GDM diagnosed from January/2014 to December/2015 were enr...

Background: Cladodes of the nopal opuntia streptacantha (prickly-pear cactus) have been traditionally used for the treatment of diabetes in Mexico. Limited data from studies in experimental animals and humans with prediabetes or type 2 diabetes (DM2), have shown promising antihyperglycemic effects using plant extracts of the streptacantha and ficus-indica opuntia species. The purpose of this study was to assess the effect of opuntia ficus-indica<...

Introduction: It is known that hypothyroidism has multiple etiologies including tyrosinkinase inhibitors (TKI) agents which can cause thyroid disfunction through different mecanisms, not fully defined yet- Vascular endothelial growth factor receptor (VEGFR) blockade, thyroiditis, iodine uptake blockade, increased activity of deiodinase 3, increased hormone clearance. Some recent trials suggest that there is a correlation between the incidence of hypothyroidism and the outcome ...

Introduction: Prader-Willi syndrome (PWS) is a neurobehavioral imprinting disorder, which arises due to an absence of paternally expressed genes within the 15q11.2-q13 region. It is the most common syndromic form of obesity, with an estimated prevalence of about 1 in 25,000 individuals.Case report: we report the case of two monozygotic twins, 20-year-old, naturally conceived, both affected by PWS. They were born by eutocic delivery at 34 weeks of gestati...

BackgroundData on clinical characteristics and natural history of patients with non-functioning pituitary microadenomas (NFPmA) is limited to small-scale studies.MethodsA retrospective evaluation of initial clinical presentation and natural history of patients with NFPmA (conservatively managed, years; 2004–2020) was undertaken. Initial symptoms, tumor size, and pituitary function were assessed. Exclusio...